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From Dental to Mental Institutions: An American Dentist and a British Psychiatrist Highlight Insanity Following Nitrous-Oxide Administration

  • Author Footnotes
    1 Neither author has any intellectual, ethical, or financial conflicts of interest.
    Matthew L. Edwards
    Footnotes
    1 Neither author has any intellectual, ethical, or financial conflicts of interest.
    Affiliations
    Psychiatry & Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Rd, Stanford, CA 94305-5717, USA
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  • Author Footnotes
    1 Neither author has any intellectual, ethical, or financial conflicts of interest.
    George S. Bause
    Correspondence
    Corresponding author at: 5247 Wilson Mills Rd, No. 282, Cleveland, OH 44143-3016.
    Footnotes
    1 Neither author has any intellectual, ethical, or financial conflicts of interest.
    Affiliations
    Anesthesiology and Perioperative Medicine, Case Western Reserve University School of Medicine, 11100 Euclid Ave, Cleveland, OH 44106-6031, USA

    Oral and Maxillofacial Surgery, Case Western Reserve University School of Dental Medicine, 2124 Cornell Rd, Cleveland, OH 44106-3804, USA

    Honorary Curator and Laureate of the History of Anesthesia, Wood Library-Museum of Anesthesiology, American Society of Anesthesiologists, 1061 American Ln, Schaumburg, IL 60173-4973, USA
    Search for articles by this author
  • Author Footnotes
    1 Neither author has any intellectual, ethical, or financial conflicts of interest.
Published:February 08, 2018DOI:https://doi.org/10.1016/j.janh.2018.02.002

      Highlights

      • FW Hewitt taught oxygenating nitrous-oxide anesthetics and maintaining airway patency.
      • SJ Hayes warned of insanity after administering unoxygenated nitrous-oxide anesthesia.
      • GH Savage published many cases of post-anesthetic insanity admitted to mental asylums.

      Abstract

      In 1887, American dentist Samuel J. Hayes published reports associating unoxygenated anesthetics with asphyxia and insanity, and then British psychiatrist George H. Savage published a report of cases of insanity following nitrous-oxide anesthesia in British journals.

      Keywords

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